Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20
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منابع مشابه
Structural Basis of Presequence Recognition by the Mitochondrial Protein Import Receptor Tom20
Most mitochondrial proteins are synthesized in the cytosol as precursor proteins with a cleavable N-terminal presequence and are imported into mitochondria. We report here the NMR structure of a general import receptor, rat Tom20, in a complex with a presequence peptide derived from rat aldehyde dehydrogenase. The cytosolic domain of Tom20 forms an all alpha-helical structure with a groove to a...
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Most mitochondrial preproteins are maintained in a loosely folded import-competent conformation by cytosolic chaperones, and are imported into mitochondria by translocator complexes containing a preprotein receptor, termed translocase of the outer membrane of mitochondria (Tom) 20. Using two-hybrid screening, we identified arylhydrocarbon receptor-interacting protein (AIP), an FK506-binding pro...
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-Synuclein is likely to play a role in neurodegenerative processes, including the degeneration of nigrostriatal dopaminergic neurons that underlies Parkinson’s disease. However, the toxicological properties of -synuclein remain relatively unknown. Here, the relationship between -synuclein expression and neuronal injury was studied in mice exposed to the herbicide paraquat. Paraquat neurotoxicit...
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ژورنال
عنوان ژورنال: npj Parkinson's Disease
سال: 2020
ISSN: 2373-8057
DOI: 10.1038/s41531-020-00139-6